2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. E3 Ligase Ligand-Linker Conjugates Isoform
  6. E3 Ligase Ligand-Linker Conjugates Inhibitor

E3 Ligase Ligand-Linker Conjugates Inhibitor

E3 Ligase Ligand-Linker Conjugates Inhibitor (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141431
    Cbl-b-IN-2 2503325-21-9
    Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent.
    Cbl-b-IN-2